periodontal diseases

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	259
interventional	166
Observational	83
Registry	10

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Procedure	51
Other	23
Drug	20
Device	11
Drug|placebo	11
Drug|Procedure	9
Behavioral	5
Device|Procedure	5
Device|Other	4
Device|Drug|Procedure	3
Diagnostic Test	3
placebo|Procedure	3
Device|Drug	2
Dietary Supplement	2
Dietary Supplement|placebo	2
Drug|Other	2
Other|Procedure	2
Behavioral|Procedure	1
Biological	1
Biological|Drug	1
Biological|placebo	1
Device|placebo	1
Drug|placebo|Procedure	1
Genetic	1
Other|placebo	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
NA	35
Brazil	29
United States	28
Turkey	9
Italy	8
Norway	6
India	5
Canada	4
Egypt	4
France	4
Germany	3
Pakistan	3
Sweden	3
Chile	2
Hong Kong	2
Korea, Republic of	2
Malaysia	2
Netherlands	2
United Kingdom	2
Australia	1
Greece	1
Hungary	1
Iraq	1
Japan	1
Nigeria	1
Norway|Turkey	1
Poland	1
Saudi Arabia	1
Slovenia	1
Spain	1
United Arab Emirates	1
United States|Canada	1

Sites per Study

Site_count	Study_Count
1	153
2	9
3	1
4	1
6	1
26	1

Phase

Phase	Study_Count
N/A	115
Phase 4	23
Phase 2	13
Phase 3	8
Phase 2/Phase 3	6
Early Phase 1	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	11
2	109
3	28
4	7
5	3
6	3
NA	5

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	18	2.0000	15	10.00000	10.00	15.00000
1st Qu.	18	30.0000	40	21.00000	32.25	30.50000
Median	18	51.0000	60	28.00000	61.00	41.00000
Mean	18	157.1739	122	26.66667	224.75	56.69565
3rd Qu.	18	87.0000	154	33.50000	176.50	61.00000
Max.	18	9365.0000	400	40.00000	1101.00	303.00000

Trial Group Type

group_type	Group_Count
Experimental	158
Active Comparator	122
Placebo Comparator	47
No Intervention	25
Other	17
Sham Comparator	5
NA	5

Intervention Model

intervention_model	Study_Count
Parallel Assignment	136
Single Group Assignment	15
Crossover Assignment	11
Factorial Assignment	3
NA	1

Primary Purpose

primary_purpose	Study_Count
Treatment	115
Prevention	23
Diagnostic	11
Supportive Care	7
Other	4
NA	3
Basic Science	2
Health Services Research	1

Observational Studies

Studies by Country

Country	Study_Count
NA	19
United States	19
Turkey	8
India	6
Brazil	5
Italy	5
Egypt	3
France	3
Germany	2
Romania	2
Turkey|United Kingdom	2
Argentina	1
Canada	1
Denmark	1
Greece	1
Poland	1
Spain	1
Sweden	1
Syrian Arab Republic	1
United Kingdom	1

Sites per Study

Site_count	Study_Count
1	77
2	3
5	2
6	1

Enrollment Metrics

Measure	Observational
Min	15.0000
1st Qu	60.0000
Median	88.0000
Mean	835.9759
3rd Qu	200.0000
Max	45000.0000

Observation Model

observational_model	Study_Count
Case-Control	24
Cohort	24
Case Control	14
Other	14
Case-Only	5
NA	2

Time Perspective

time_perspective	Study_Count
Cross-Sectional	34
Prospective	34
Other	8
Retrospective	6
NA	1

Registries

Studies by Country

Country	Study_Count
NA	5
Egypt	1
Italy	1
Japan	1
Spain	1
Turkey	1

Sites per Study

Site_count	Study_Count
1	10

Enrollment Metrics

Measure	Registries
Min	39.0
1st Qu	82.5
Median	109.5
Mean	181.8
3rd Qu	120.0
Max	750.0

Registry Model

observational_model	Study_Count
Case-Control	6
Cohort	3
Other	1

Time Perspective

time_perspective	Study_Count
Cross-Sectional	4
Other	3
Prospective	3

Follow-up

target_duration	Study_Count
1 Day	2
10 Months	1
12 Months	1
15 Days	1
2 Days	1
2 Weeks	1
2 Years	1
3 Days	1
6 Months	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03368430	Melatonin as an Adjunctive Therapy for Chronic Periodontitis.	https://ClinicalTrials.gov/show/NCT03368430	Completed	Mansoura University	2017-06-08
NCT03364751	Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome	https://ClinicalTrials.gov/show/NCT03364751	Completed	Philip Morris Products S.A.	2018-12-21
NCT03336957	Stress and Gingival Inflammation in Non-pregnant and Pregnant Women	https://ClinicalTrials.gov/show/NCT03336957	Completed	Tokat Gaziosmanpasa University	2017-01-01
NCT03316755	Risk Perception of Periodontal Disease	https://ClinicalTrials.gov/show/NCT03316755	Completed	University of Benin	2017-10-04
NCT02514226	Evaluation of Periodontal Treatment in Patients With Bronchiectasis	https://ClinicalTrials.gov/show/NCT02514226	Enrolling by invitation	University of Nove de Julho	2020-07-31
NCT03262402	Effects of Periodontal Treatment on HIV-infected Patients	https://ClinicalTrials.gov/show/NCT03262402	Completed	University of Sao Paulo	2018-08-02
NCT03262077	Dose Parameters for Photodynamic Therapy on Periodontal Disease	https://ClinicalTrials.gov/show/NCT03262077	Completed	University of Nove de Julho	2017-06-26
NCT03241953	COMPARISION OF DIFFERENT TREATMENT METHODS OF PERI-IMPLANTITIS	https://ClinicalTrials.gov/show/NCT03241953	Completed	Necmettin Erbakan University	2016-11-20
NCT03227367	Osteoclast Impairment in Chronic Periodontitis by Regenerative Materials.	https://ClinicalTrials.gov/show/NCT03227367	Completed	Meenakshi Ammal Dental College and Hospital	2016-04-13
NCT03219840	Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis	https://ClinicalTrials.gov/show/NCT03219840	Completed	The University of Texas Health Science Center, Houston	2018-09-08
NCT03198832	oxLDL in Diabetes Mellitus Patients and Disease Periodontal	https://ClinicalTrials.gov/show/NCT03198832	Completed	Universidade Estadual Paulista Júlio de Mesquita Filho	2016-08-26
NCT03197610	The Effect of Enamel Matrix Derivatives on Root Coverage Esthetic Score	https://ClinicalTrials.gov/show/NCT03197610	Completed	Yuzuncu Yıl University	2016-07-01
NCT03196648	Randomized Trial of a Gum Health Formulation	https://ClinicalTrials.gov/show/NCT03196648	Completed	Glo Science, Inc.	2016-11-30
NCT03191721	Triclosan Toothpaste in the Maintenance Phase of Peri-implantitis Treatment.	https://ClinicalTrials.gov/show/NCT03191721	Completed	University of Guarulhos	2014-12-31
NCT03190512	Periodontal Treatment and Psychology	https://ClinicalTrials.gov/show/NCT03190512	Completed	Tokat Gaziosmanpasa University	2016-03-31
NCT03181386	Tooth Extraction in Patients With Atrial Fibrillation in Use of New Oral Anticoagulants	https://ClinicalTrials.gov/show/NCT03181386	Active, not recruiting	University of Sao Paulo General Hospital	2020-07-30
NCT03117153	Effect of a Liquid Toothpaste on Periodontal Disease	https://ClinicalTrials.gov/show/NCT03117153	Completed	Dong-A Pharmaceutical	2014-09-15
NCT03102892	Antimicrobial Photodynamic Therapy on Periodontal Treatment and Salivary Status of Type 1 Diabetes Mellitus Patients	https://ClinicalTrials.gov/show/NCT03102892	Recruiting	University of Sao Paulo	2020-10-10
NCT03095976	Amnion-Chorion Allograft Barrier Used for Root Surface and Guided Tissue Regeneration for Periodontal Intrabony Defects and Grade II Furcation Defects.	https://ClinicalTrials.gov/show/NCT03095976	Recruiting	Indiana University	2019-10-15
NCT02982681	Bioactive Glass and Platelet Rich Fibrin in Intrabony Defects	https://ClinicalTrials.gov/show/NCT02982681	Completed	Dr. D. Y. Patil Dental College & Hospital	2016-08-31
NCT02938988	Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down’s Syndrome Patients	https://ClinicalTrials.gov/show/NCT02938988	Completed	University of Sao Paulo	2016-10-31
NCT02935322	Interaction Between Chlorhexidine and Fluoride	https://ClinicalTrials.gov/show/NCT02935322	Completed	University of Oslo	2011-12-31
NCT02914743	Providing Preventive Periodontal Treatment to Hospitalized Patients With Diabetes	https://ClinicalTrials.gov/show/NCT02914743	Completed	Massachusetts General Hospital	2017-10-02
NCT02866929	A Biotype Enhancing Strategy For The Patient Undergoing Accelerated Orthodontics	https://ClinicalTrials.gov/show/NCT02866929	Active, not recruiting	CES University	2018-06-30
NCT02793453	Antimicrobial Peptides in Periodontitis	https://ClinicalTrials.gov/show/NCT02793453	Completed	CHU de Reims	2016-03-23
NCT02774967	Comparation Between Two Surgical Techniques With Acellular Dermal Matrix in Treatment of Gingival Recessions	https://ClinicalTrials.gov/show/NCT02774967	Completed	University of Sao Paulo	2016-01-31
NCT02761993	Safety, Efficacy and Treatment Regimen Study of ST266 in Subjects With Moderate to Severe Periodontitis	https://ClinicalTrials.gov/show/NCT02761993	Completed	Noveome Biotherapeutics, formerly Stemnion	2017-10-31
NCT02756377	A Comparison of Mouth Rinse Containing Alcohol-free Chlorhexidine With a Cetylpyridinium Chloride in Periodontal Diseases	https://ClinicalTrials.gov/show/NCT02756377	Completed	Islamic Azad University, Tehran	2015-04-30
NCT02735837	The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®	https://ClinicalTrials.gov/show/NCT02735837	Completed	Islamic Azad University, Tehran	2016-03-31
NCT02670135	Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers	https://ClinicalTrials.gov/show/NCT02670135	Completed	Colgate Palmolive	2016-07-31
NCT02666573	Photodynamic Therapy During Supportive Periodontal Therapy	https://ClinicalTrials.gov/show/NCT02666573	Completed	National University, Singapore	2014-12-31
NCT02618486	The Effects of Obesity on Non Surgical Periodontal Therapy	https://ClinicalTrials.gov/show/NCT02618486	Completed	University of Malaya	2015-09-30
NCT02613468	Periodontal Condition in Pregnancy and Low Birth Delivery Incidence	https://ClinicalTrials.gov/show/NCT02613468	Completed	Ondokuz Mayıs University	2004-12-31
NCT02585596	A Phase II Clinical Trial of YH23537 in Patients With Chronic Periodontal Disease.	https://ClinicalTrials.gov/show/NCT02585596	Completed	Yuhan Corporation	2016-12-28
NCT02560870	Compare the Efficacy of Aloe Vera Mouthwash With Non- Alcoholic Chlorhexidine Mouthwash on Periodontal Diseases	https://ClinicalTrials.gov/show/NCT02560870	Completed	Islamic Azad University, Tehran	2015-04-30
NCT02543502	Treatment of Periodontal Disease in Patients With Acute Myocardial Infarction	https://ClinicalTrials.gov/show/NCT02543502	Completed	Instituto de Cardiologia do Rio Grande do Sul	2015-01-31
NCT02541032	PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke	https://ClinicalTrials.gov/show/NCT02541032	Recruiting	University of South Carolina	2019-06-30
NCT02538237	the Effect of Sub-gingival Irrigation With Ibuprofen 2% Mouthwash in Treatment of Periodontal Diseases.	https://ClinicalTrials.gov/show/NCT02538237	Completed	Islamic Azad University, Tehran	2014-08-31
NCT02508415	Relationship Between Obesity and Periodontal Disease	https://ClinicalTrials.gov/show/NCT02508415	Completed	University of Malaya	2014-01-31
NCT02500654	Regenerative Surgical Treatment of Peri-implantitis	https://ClinicalTrials.gov/show/NCT02500654	Completed	Region Gävleborg	2014-01-31
NCT02487186	Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy.	https://ClinicalTrials.gov/show/NCT02487186	Completed	University of Campinas, Brazil	2014-12-31
NCT02474498	EMD and/or Bone Substitute for the Treatment of Class II Furcations	https://ClinicalTrials.gov/show/NCT02474498	Completed	University of Campinas, Brazil	2014-12-31
NCT02463006	Porous and Non-porous Bone Grafts in Intra-bony Periodontal Defects	https://ClinicalTrials.gov/show/NCT02463006	Completed	Dr. D. Y. Patil Dental College & Hospital	2014-09-30
NCT02461030	Efficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Periodontal Treatment	https://ClinicalTrials.gov/show/NCT02461030	Completed	University of Campinas, Brazil	2014-11-30
NCT02460926	Acute Phase Response & Periodontal Treatment	https://ClinicalTrials.gov/show/NCT02460926	Completed	University of Pisa	2013-10-31
NCT03386877	Periodontal Regeneration Using Dental Pulp Stem Cells (DPSCs)	https://ClinicalTrials.gov/show/NCT03386877	Completed	University of Turin, Italy	2017-04-28
NCT02375178	Antimicrobial Activity of Two Mouthwashes	https://ClinicalTrials.gov/show/NCT02375178	Completed	Universidade do Vale do Sapucai	2014-10-31
NCT02368678	“Study of Halitosis in Patients With Advanced Chronic Periodontitis”	https://ClinicalTrials.gov/show/NCT02368678	Completed	Federal University of Minas Gerais	2014-05-31
NCT02333227	Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi	https://ClinicalTrials.gov/show/NCT02333227	Active, not recruiting	Baylor College of Medicine	2020-12-31
NCT02220751	Diagnostic Biomarkers Related to Periodontal Disease Activity in Diabetic	https://ClinicalTrials.gov/show/NCT02220751	Completed	University of Sao Paulo	2011-09-30
NCT02185209	Surgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics	https://ClinicalTrials.gov/show/NCT02185209	Recruiting	Karolinska Institutet	2021-10-31
NCT02180932	Towards a Viral Etiology of Periodontal Disease in Relation to Radiotherapy Treatment of Head and Neck Cancers	https://ClinicalTrials.gov/show/NCT02180932	Completed	Centre Hospitalier Universitaire de Nice	2015-07-31
NCT02172716	Disruption of Immune Homeostasis in Type 2 Diabetics With Generalized Chronic Periodontitis	https://ClinicalTrials.gov/show/NCT02172716	Completed	University of Sao Paulo	2015-05-31
NCT02126267	Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection	https://ClinicalTrials.gov/show/NCT02126267	Completed	Centro Universitario de Lavras	2014-02-28
NCT02102360	Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial.	https://ClinicalTrials.gov/show/NCT02102360	Completed	University of Sao Paulo	2013-11-30
NCT01291875	Periodontal Treatment and Metabolic Control in Type 2 Diabetic Patients	https://ClinicalTrials.gov/show/NCT01291875	Completed	University of Sao Paulo	2014-02-28
NCT01951547	The Periodontal Disease and Diabetes Mellitus Interrelationship Among Adult Malaysians	https://ClinicalTrials.gov/show/NCT01951547	Completed	University of Malaya	2011-12-31
NCT01950962	Role Of Phospholipid Transfer Proteins (Pltp) On Endotoxemia Caused By Buccal Inflammation	https://ClinicalTrials.gov/show/NCT01950962	Completed	Centre Hospitalier Universitaire Dijon	2014-06-12
NCT04450849	Regenerative Potential of a Collagen Membrane Associated or Not to Bovine Bone in Class II Furcation Defects.	https://ClinicalTrials.gov/show/NCT04450849	Completed	University of Sao Paulo	2019-06-15
NCT01852253	Implant Surface Decontamination With 2 % Chlorhexidine in Peri-implantitis Treatment	https://ClinicalTrials.gov/show/NCT01852253	Completed	University Medical Center Groningen	2013-04-30
NCT01811615	Efficacy of New Alcohol Free Mouthrinses	https://ClinicalTrials.gov/show/NCT01811615	Completed	University of Witten/Herdecke	2011-02-28
NCT01802216	Kidney and Periodontal Disease Study	https://ClinicalTrials.gov/show/NCT01802216	Completed	University of California, San Francisco	2017-09-30
NCT01798225	Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population	https://ClinicalTrials.gov/show/NCT01798225	Completed	Medical University of South Carolina	2010-01-31
NCT01742559	The Anesthetic Effect of Anterior Middle Superior Alveolar Technique	https://ClinicalTrials.gov/show/NCT01742559	Completed	State University of Maringá	2010-08-31
NCT01718912	Periodontal Disease Treatment of a Physically Challenged Population	https://ClinicalTrials.gov/show/NCT01718912	Completed	Oravital Inc	2014-09-30
NCT01670305	Photodynamic Therapy and Periodontal Therapy. A Clinical, Microbiological and Immunoenzymatic Analysis	https://ClinicalTrials.gov/show/NCT01670305	Completed	Paulista University	2011-05-31
NCT01639183	Power Toothbrush Use in Nursing Homes to Eliminate Mouth and Body Inflammation	https://ClinicalTrials.gov/show/NCT01639183	Completed	University of Manitoba	2013-07-31
NCT01595594	Comparison Between aPDT and Systemic Doxycycline on Non-surgical Periodontal Therapy in Type 2 Diabetics	https://ClinicalTrials.gov/show/NCT01595594	Completed	University of Sao Paulo	2012-04-30
NCT01591616	Pediatric Study to Access Pharmacokinetics and Safety of Oraqix Gel	https://ClinicalTrials.gov/show/NCT01591616	Completed	Dentsply International	2012-04-30
NCT01533792	Effect of Non-surgical Periodontal Treatment	https://ClinicalTrials.gov/show/NCT01533792	Completed	Universidade Federal do Maranhão	2010-12-31
NCT01521260	Implant Surface Decontamination in Peri-implantitis Treatment	https://ClinicalTrials.gov/show/NCT01521260	Completed	University Medical Center Groningen	2011-09-30
NCT01499225	A Clinical Trial of YH14642 in Patients With Chronic Periodontal Disease	https://ClinicalTrials.gov/show/NCT01499225	Completed	Yuhan Corporation	2013-07-31
NCT01427764	Dentin Hypersensitivity Following Non-surgical Periodontal Therapy With Hand or Ultrasonic Instruments	https://ClinicalTrials.gov/show/NCT01427764	Completed	Escola Bahiana de Medicina e Saude Publica	2010-01-31
NCT01422122	Study of Vitamin D Supplementation on Improvement of Gums Health	https://ClinicalTrials.gov/show/NCT01422122	Completed	Aga Khan University	2011-10-31
NCT04425343	Microbial Profiling in Pockets Related to Chronic Periodontitis Patients Using 16s RNA Metagenomics Sequencing	https://ClinicalTrials.gov/show/NCT04425343	Completed	Ajman University	2018-09-15
NCT04422184	Comparative Clinical Evaluation of Three Different Agents in Reducing Dental Hypersensitivity in Periodontal Patients	https://ClinicalTrials.gov/show/NCT04422184	Recruiting	University of Sao Paulo	2020-11-30
NCT04404374	Treatment of Periodontal Intrabony Defects With A-PRF+ or EMD	https://ClinicalTrials.gov/show/NCT04404374	Active, not recruiting	Semmelweis University	2020-06-30
NCT04399187	Adjunctive Local Sodium Hypochlorite Gel in Non Surgical Periodontal Debridement	https://ClinicalTrials.gov/show/NCT04399187	Completed	University of Messina	2019-09-01
NCT04399135	Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal Pocket	https://ClinicalTrials.gov/show/NCT04399135	Active, not recruiting	Qassim University	2021-02-25
NCT04390997	Determination of the Levels of Lipocalin-2 and Semaphorin3A	https://ClinicalTrials.gov/show/NCT04390997	Recruiting	Izmir Katip Celebi University	2020-09-30
NCT04381403	Development of a New Toothpaste for the Removal of Dental Calculus.	https://ClinicalTrials.gov/show/NCT04381403	Active, not recruiting	McGill University Health Centre/Research Institute of the McGill University Health Centre	2019-03-10
NCT04356391	Pinhole Surgical Technique Compared to Connective Tissue Graft in Treatment of Gingival Recession	https://ClinicalTrials.gov/show/NCT04356391	Active, not recruiting	State University of New York at Buffalo	2020-06-30
NCT04345744	Evaluation of the Rinse With Chlorhexidine Plus Hyaluronic Acid Mouthwash in Periodontal Surgical Wound Healing	https://ClinicalTrials.gov/show/NCT04345744	Completed	University of Pisa	2018-12-31
NCT04332965	Periostin and Non-Surgical Periodontal Treatment	https://ClinicalTrials.gov/show/NCT04332965	Completed	Kırıkkale University	2018-01-31
NCT04251858	Evaluation of Oral Condition and the Effect of Dental Treatment on Physical Parameters of Athletes	https://ClinicalTrials.gov/show/NCT04251858	Recruiting	Universidade Metropolitana de Santos	2020-11-10
NCT04237662	Enamel Matrix Derivatives & Periodontal Therapy in Diabetic Patients	https://ClinicalTrials.gov/show/NCT04237662	Recruiting	University of Pisa	2023-01-01
NCT04223076	Clinical Effect of Chlorhexidine Mouthwash After Periodontal Surgery	https://ClinicalTrials.gov/show/NCT04223076	Recruiting	University of Oslo	2019-12-20
NCT04209777	Clinical Evaluation of Smoker Periodontal Subjects After Lactobacillus-reuteri Probiotics and Antibiotics Therapy	https://ClinicalTrials.gov/show/NCT04209777	Completed	Dow University of Health Sciences	2019-04-16
NCT04198610	Evaluation and Correlation of Serum Fetuin-A Levels in Periodontal Health and Disease: A Clinico-biochemical Study	https://ClinicalTrials.gov/show/NCT04198610	Completed	Krishnadevaraya College of Dental Sciences & Hospital	2017-08-28
NCT04180332	Anti Oxidant Enzymes and Total Antioxidant Levels in Diabetes Mellitus Type II Patients and Healthy Individuals With Periodontitis	https://ClinicalTrials.gov/show/NCT04180332	Completed	Ajman University	2018-08-10
NCT04173156	Treatment of Advanced Periodontitis Using an Oscillating Chitosan Device Versus Regular Curettes Alone	https://ClinicalTrials.gov/show/NCT04173156	Recruiting	Labrida AS	2020-01-15
NCT04169139	Controlled Study Comparing REPaiR® and MIST Therapies for Treatment of Periodontitis	https://ClinicalTrials.gov/show/NCT04169139	Active, not recruiting	McGuire Institute	2020-05-15
NCT04149327	Systemic Amoxicillin Plus Metronidazole in Peri-implantitis Treatment	https://ClinicalTrials.gov/show/NCT04149327	Completed	University Medical Center Groningen	2019-12-31
NCT04145557	980nm Diode Laser in the Treatment of Periodontal Disease in Cardiac Patients	https://ClinicalTrials.gov/show/NCT04145557	Recruiting	Pomeranian Medical University Szczecin	2020-04-30
NCT04117451	The Effect of Propolis Mouthwash Compared to Chlorhexidine Mouthwash on Oral and Cardiovascular Health	https://ClinicalTrials.gov/show/NCT04117451	Recruiting	University of Plymouth	2020-07-01
NCT04082949	Autologous Fibrin Glue Application as an Adjunct to Nonsurgical Periodontal Treatment of Chronic Periodontitis	https://ClinicalTrials.gov/show/NCT04082949	Completed	Inonu University	2018-12-10
NCT04059458	Mandibular Furcation III Regeneration (FURC-III-REGEN)	https://ClinicalTrials.gov/show/NCT04059458	Recruiting	University of Oslo	2027-06-15
NCT04059445	Mandibular Furcation II Regeneration	https://ClinicalTrials.gov/show/NCT04059445	Recruiting	University of Oslo	2027-06-15
NCT04051385	Assesment of Gingival Crevicular Fluid and Serum ErbB4/Neuregulin-4 Levels in Periodontal Disease and Health	https://ClinicalTrials.gov/show/NCT04051385	Completed	Abant Izzet Baysal University	2019-01-18
NCT04051255	Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis.	https://ClinicalTrials.gov/show/NCT04051255	Active, not recruiting	University of Campinas, Brazil	2020-03-01
NCT04036513	Minimally Invasive Non Surgical Therapy Versus Conventional Scaling and Root Planing for Treatment of Periodontitis	https://ClinicalTrials.gov/show/NCT04036513	Recruiting	University of Ljubljana	2021-04-02
NCT04023500	Supporting Oral Self-care of Patients With Periodontitis Through Motivational Interview	https://ClinicalTrials.gov/show/NCT04023500	Active, not recruiting	University of Turku	2015-11-01
NCT04017429	Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade III Furcation Defects (FURC-III-OST)	https://ClinicalTrials.gov/show/NCT04017429	Recruiting	University of Oslo	2027-06-15
NCT04015427	Cement Excess at Single Implant Crowns Malmö/Lund	https://ClinicalTrials.gov/show/NCT04015427	Recruiting	University of Zurich	2019-12-31
NCT04006249	Haemochromatosis and Periodontitis	https://ClinicalTrials.gov/show/NCT04006249	Completed	Rennes University Hospital	2011-09-22
NCT03971981	Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect	https://ClinicalTrials.gov/show/NCT03971981	Completed	Università degli Studi di Sassari	2018-05-31
NCT03923465	Entire Papilla Preservation Technique With and Without Biomaterials in the Treatment of Isolated Intrabony Defects	https://ClinicalTrials.gov/show/NCT03923465	Completed	Dr. Aslan Private Perio Center	2018-09-16
NCT03919006	Netrin 1 and Its Receptor Unc5b as Markers of Periodontal Disease	https://ClinicalTrials.gov/show/NCT03919006	Completed	Abant Izzet Baysal University	2019-02-01
NCT03917030	Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade II Furcation Defects	https://ClinicalTrials.gov/show/NCT03917030	Recruiting	University of Oslo	2027-04-15
NCT03908606	Serum Hs-CRP in Periodontitis Patients With or Without Diabetes	https://ClinicalTrials.gov/show/NCT03908606	Completed	Cairo University	2019-01-02
NCT03839719	OSE as a Pre-procedural Mouth Rinse: A Clinical and Microbiological Study.	https://ClinicalTrials.gov/show/NCT03839719	Completed	Government College of Dentistry, Indore	2019-04-26
NCT03816930	Evaluation of Gingival Health Parameters in Hybrid CAD / CAM Crowns Produced After Different Retraction Processes	https://ClinicalTrials.gov/show/NCT03816930	Active, not recruiting	Yuzuncu Yıl University	2020-01-17
NCT03814434	Surgical Treatment of Periimplantitis in Patients With Risk Factors	https://ClinicalTrials.gov/show/NCT03814434	Recruiting	University of Sao Paulo	2020-01-28
NCT03790904	Anti Plaque Efficacy of Salvadora Persica L. and Green Tea Mouthwash	https://ClinicalTrials.gov/show/NCT03790904	Completed	University of Baghdad	2019-03-31
NCT03765151	The Effectiveness of Low-level Laser Therapy in Orthodontic Retention for Periodontal-compromised Patients	https://ClinicalTrials.gov/show/NCT03765151	Recruiting	The University of Hong Kong	2019-10-01
NCT03764410	Evaluation of Non - Surgical Periodontal Therapy in Diabetic Patients.	https://ClinicalTrials.gov/show/NCT03764410	Completed	Universidade Metropolitana de Santos	2017-10-15
NCT03753451	Influence of Periodontal Disease Treatment on Serum Levels of Sirtuin 1 and Mannose-binding Lectin	https://ClinicalTrials.gov/show/NCT03753451	Completed	InCor Heart Institute	2018-10-01
NCT03729167	Instrumentation Effectiveness of Modified, Area-Specific Hand Scalers During Non-Surgical Periodontal Therapy	https://ClinicalTrials.gov/show/NCT03729167	Completed	University of Michigan	2019-06-17
NCT03715374	Platelet-Rich Fibrin and Anorganic Bovine Bone vs Collagen Membrane and Anorganic Bovine Bone in Intrabony Defects	https://ClinicalTrials.gov/show/NCT03715374	Completed	G. d’Annunzio University	2018-11-16
NCT03694496	The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong	https://ClinicalTrials.gov/show/NCT03694496	Recruiting	The University of Hong Kong	2020-07-28
NCT03671512	Standard Root Planing vs. Periodontal Structure Repair Device for Treatment of Pockets Caused by Periodontal Disease	https://ClinicalTrials.gov/show/NCT03671512	Completed	Periovance, Inc	2020-01-17
NCT03641989	Correlation Between Oral Health and Systemic Inflammation (COHESION)	https://ClinicalTrials.gov/show/NCT03641989	Completed	Marshfield Clinic Research Foundation	2019-12-30
NCT03628872	Treatment of Periodontitis With Er:YAG Laser	https://ClinicalTrials.gov/show/NCT03628872	Completed	Columbia University	2019-05-01
NCT03622255	Evaluation of Enamel Matrix Derivative as an Adjunct to Minimally Invasive Non-surgical Treatment of Intrabony Defects.	https://ClinicalTrials.gov/show/NCT03622255	Recruiting	Aristotle University Of Thessaloniki	2019-12-30
NCT03550651	Evaluation of Antiplaque Efficacy of Licorice Extract Mouthrinse & HSS and Their Comparison With EO & CHX Mouthrinse	https://ClinicalTrials.gov/show/NCT03550651	Completed	Government College of Dentistry, Indore	2017-05-15
NCT03544931	Enamel Matrix Derivatives on Systemic Inflammation After Periodontal Therapy	https://ClinicalTrials.gov/show/NCT03544931	Completed	University of Pisa	2018-01-01
NCT03540498	Study of Colonization of Strains L.Plantarum and L.Brevis in the Product AB-DENTALAC Chewing Gum	https://ClinicalTrials.gov/show/NCT03540498	Completed	AB Biotics, SA	2016-11-24
NCT03525457	Response to Periodontal Therapy in a Chronic Kidney Disease Population	https://ClinicalTrials.gov/show/NCT03525457	Recruiting	Pontificia Universidad Catolica de Chile	2019-08-31
NCT03501316	The Immune Response After Periodontal Treatment	https://ClinicalTrials.gov/show/NCT03501316	Completed	University of Glasgow	2019-08-01
NCT03474146	Comparative Evaluation of Antiplaque and Antigingivitis Efficacy of Ocimum Sanctum (Tulsi) Extract	https://ClinicalTrials.gov/show/NCT03474146	Completed	Government College of Dentistry, Indore	2017-07-22
NCT03452891	Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients	https://ClinicalTrials.gov/show/NCT03452891	Recruiting	University of Nebraska	2020-07-01
NCT03444363	Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus	https://ClinicalTrials.gov/show/NCT03444363	Completed	Çanakkale Onsekiz Mart University	2014-02-15
NCT03442920	Evaluation of Periodontal Diseases and Obesity in Women	https://ClinicalTrials.gov/show/NCT03442920	Completed	Kocaeli University	2015-06-11
NCT01215201	Diode Laser Study for Periodontal Maintenance Patients	https://ClinicalTrials.gov/show/NCT01215201	Completed	University of Nebraska	2011-06-30
NCT01201746	Influence of Periodontal Treatment on Systemic Inflammatory Mediators	https://ClinicalTrials.gov/show/NCT01201746	Completed	Sheikh Zayed Federal Postgraduate Medical Institute	2009-04-30
NCT01198509	Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)	https://ClinicalTrials.gov/show/NCT01198509	Completed	NYU Langone Health	2013-01-31
NCT01128374	The Effect of Non-Surgical Periodontal Therapy on Glycemic Control and Bacterial Levels in a Mexican-American Population With Type 2 Diabetes	https://ClinicalTrials.gov/show/NCT01128374	Completed	The University of Texas Health Science Center, Houston	2012-09-30
NCT01118143	Oral Health Literacy Tailored Communication	https://ClinicalTrials.gov/show/NCT01118143	Completed	University of Tromso	2012-02-29
NCT01113528	Omega-3 and Aspirin in Periodontal Regeneration	https://ClinicalTrials.gov/show/NCT01113528	Completed	October 6 University	2009-12-31
NCT01046435	Effects of Periodontal Therapy on Systemic Inflammation	https://ClinicalTrials.gov/show/NCT01046435	Completed	University of Chile	2009-03-31
NCT00955643	Periodontal Treatment Associated With Hyperbaric Oxygen Therapy	https://ClinicalTrials.gov/show/NCT00955643	Completed	Escola Bahiana de Medicina e Saude Publica	NA
NCT00937976	Treatment for Periodontal Disease in Dialysis Patients	https://ClinicalTrials.gov/show/NCT00937976	Completed	University of North Carolina, Chapel Hill	2010-06-30
NCT00893802	Influence of Periodontal Treatment During Pregnancy in Adverse Pregnant Outcomes	https://ClinicalTrials.gov/show/NCT00893802	Completed	University of Sao Paulo	2002-08-31
NCT03244943	Cytokine Profiles in Breast Cancer Patients Undergoing Chemotherapy	https://ClinicalTrials.gov/show/NCT03244943	Completed	University of Sao Paulo	2016-12-12
NCT03620396	Comparison of Serum Trefoil Factor 3 in Patients With Gingivitis and Periodontitis After Scaling and Root Planing	https://ClinicalTrials.gov/show/NCT03620396	Completed	Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre	2017-01-17
NCT04330469	Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial	https://ClinicalTrials.gov/show/NCT04330469	Recruiting	Postgraduate Institute of Medical Education and Research	2021-03-30
NCT03590093	Amelogenins and Systemic Inflammation After Periodontal Surgical Therapy	https://ClinicalTrials.gov/show/NCT03590093	Completed	University of Pisa	2017-12-01
NCT02906982	Evaluating the Efficacy of a Gum Health Formulation on Teeth Whitening in Patients With Gingivitis and Periodontitis	https://ClinicalTrials.gov/show/NCT02906982	Completed	Glo Science, Inc.	2015-12-31
NCT03997552	NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration	https://ClinicalTrials.gov/show/NCT03997552	Recruiting	Universidad de Murcia	2020-09-30
NCT03939936	The Effect of Periodontal Treatment on Psoriasis	https://ClinicalTrials.gov/show/NCT03939936	Completed	Tokat Gaziosmanpasa University	2018-01-30
NCT00763256	The Effect of Periodontal Treatment and the Use of Dentifrice on Glycaemic Control in Diabetics	https://ClinicalTrials.gov/show/NCT00763256	Completed	Colgate Palmolive	2009-08-31
NCT00757159	Study on Regenerative Treatment of Intra-bony Defects	https://ClinicalTrials.gov/show/NCT00757159	Completed	Technische Universität Dresden	2012-01-31
NCT00702429	Immunoregulation of Periodontal Disease	https://ClinicalTrials.gov/show/NCT00702429	Completed	Assistance Publique Hopitaux De Marseille	2010-07-31
NCT02066337	Effect of Ozone Gel on Treatment of Chronic Periodontitis	https://ClinicalTrials.gov/show/NCT02066337	Completed	October 6 University	2014-01-31
NCT00379548	Changes in Inflammatory State in Asian Americans Changing From Traditional Asian Diets to American Diet - a Pilot Study	https://ClinicalTrials.gov/show/NCT00379548	Completed	Joslin Diabetes Center	2008-07-31
NCT00255970	Regenafil Versus Demineralized Freeze Dried Bone Allograft (DFDBA) for Periodontal Defects	https://ClinicalTrials.gov/show/NCT00255970	Completed	RTI Surgical	2007-11-30
NCT02845024	The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus	https://ClinicalTrials.gov/show/NCT02845024	Completed	Islamic Azad University, Tehran	2015-12-31
NCT00196456	Photodynamic Lasertherapy (PDT) in Periodontal Treatment (in Vivo)	https://ClinicalTrials.gov/show/NCT00196456	Completed	University Medicine Greifswald	NA
NCT00167466	Placebo Controlled Trial of a Titanium Dioxide Semiconductor Toothbrush on Mild-to-moderate Gum Disease	https://ClinicalTrials.gov/show/NCT00167466	Completed	University of Saskatchewan	2010-05-31
NCT00127244	Study Comparing Two Different Methods of Treating Periodontal Disease	https://ClinicalTrials.gov/show/NCT00127244	Completed	The Forsyth Institute	NA
NCT00093236	Impact of Gum Infection on Heart Disease	https://ClinicalTrials.gov/show/NCT00093236	Completed	Boston University	2011-04-30
NCT00066066	Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers	https://ClinicalTrials.gov/show/NCT00066066	Completed	The Forsyth Institute	2009-07-31
NCT00066001	Microbial Associations in Periodontal Health and Disease	https://ClinicalTrials.gov/show/NCT00066001	Completed	The Forsyth Institute	2007-12-31
NCT00001698	Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR	https://ClinicalTrials.gov/show/NCT00001698	Completed	National Institutes of Health Clinical Center (CC)	NA
NCT00016835	Treating Periodontal Infection: Effects on Glycemic	https://ClinicalTrials.gov/show/NCT00016835	Completed	University of Michigan	2004-09-03
NCT00004640	“Clinical Trials to Enhance Elders’ Oral Health” (“TEETH”)	https://ClinicalTrials.gov/show/NCT00004640	Completed	University of Washington	2008-05-31

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03395041	Periodontal Disease, Inflammation and Acute Coronary Syndromes	https://ClinicalTrials.gov/show/NCT03395041	Recruiting	Cardio Med Medical Center	2021-01-15
NCT03391349	Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Chronic Periodontitis and Diabetic Subjects	https://ClinicalTrials.gov/show/NCT03391349	Completed	Meenakshi Ammal Dental College and Hospital	2017-07-22
NCT03371446	DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.	https://ClinicalTrials.gov/show/NCT03371446	Completed	University of Sao Paulo	2017-10-16
NCT03787875	Impact of Periodontal Treatment on the RANKL/OPG Ratio in Crevicular Fluid	https://ClinicalTrials.gov/show/NCT03787875	Completed	University of Valencia	2016-06-05
NCT03345329	Development of a Molecular Diagnosing Platform for Relieving Periodontal Symptoms	https://ClinicalTrials.gov/show/NCT03345329	Completed	General Biologicals Corporation	2016-03-30
NCT03265821	Influence of Smoking on Periodontal Healing One Year After Active Treatment	https://ClinicalTrials.gov/show/NCT03265821	Completed	Dalarna County Council, Sweden	2015-12-31
NCT03225950	Interaction Between Immune Cells and Bacteria Associated With Periodontitis	https://ClinicalTrials.gov/show/NCT03225950	Completed	University of Copenhagen	2018-10-12
NCT03161301	Role of IL-37 Genetic Variants in Modulating Innate Immune Response to Periodontal Pathogens	https://ClinicalTrials.gov/show/NCT03161301	Completed	University of North Carolina, Chapel Hill	2019-05-24
NCT03064178	Use of Pain Medication Following Periodontal Procedures	https://ClinicalTrials.gov/show/NCT03064178	Completed	Brock University	2016-03-07
NCT02935868	Periodontal and Salivary Evaluation of Type 1 Diabetes Mellitus Patients	https://ClinicalTrials.gov/show/NCT02935868	Completed	University of Sao Paulo	2016-09-30
NCT02903264	Gestational Diabetes Mellitus, Obesity and Periodontal Disease	https://ClinicalTrials.gov/show/NCT02903264	Completed	University of Sao Paulo	2016-09-30
NCT02894463	Study Aimed at Detecting Potential Abuse of Nitrous Oxide in Children During Dental Care	https://ClinicalTrials.gov/show/NCT02894463	Completed	Nantes University Hospital	2015-05-31
NCT02848378	Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease	https://ClinicalTrials.gov/show/NCT02848378	Completed	Kırıkkale University	2015-01-31
NCT02826720	Is There a Relationship Between Hyperlipidemia and Periodontitis?	https://ClinicalTrials.gov/show/NCT02826720	Completed	Marmara University	2016-01-31
NCT02808130	PERIODONTAL DISEASE AND HYPERLIPIDEMIA	https://ClinicalTrials.gov/show/NCT02808130	Completed	Ondokuz Mayıs University	2014-08-31
NCT02794012	Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis	https://ClinicalTrials.gov/show/NCT02794012	Completed	University of Colorado, Denver	2017-12-31
NCT02789306	Preventive Maintenance Therapy on Peri-implant Diseases	https://ClinicalTrials.gov/show/NCT02789306	Completed	Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain	2017-01-01
NCT02750956	Endocan, VEGF and TNF-alpha Levels in Periodontal Disease and After Treatment	https://ClinicalTrials.gov/show/NCT02750956	Completed	Bulent Ecevit University	2015-12-31
NCT02615626	Visfatin Levels Before and After Periodontal Treatment	https://ClinicalTrials.gov/show/NCT02615626	Completed	Bulent Ecevit University	2013-10-31
NCT01712672	Bacterial Arrangement on the Teeth	https://ClinicalTrials.gov/show/NCT01712672	Completed	National Institutes of Health Clinical Center (CC)	2016-01-07
NCT02433405	Serum Amyloid A Protein And Fetuin A Levels	https://ClinicalTrials.gov/show/NCT02433405	Completed	Bulent Ecevit University	2014-04-30
NCT02394860	Influence of Periodontal Diseases on Vascular Parameters in Patients Suffering of Hypertension	https://ClinicalTrials.gov/show/NCT02394860	Recruiting	University Hospital, Strasbourg, France	2020-05-31
NCT02289066	Impact of Periodontal Disease on Outcomes in Diabetes	https://ClinicalTrials.gov/show/NCT02289066	Completed	University of Nevada, Reno	2015-06-30
NCT02184962	Periodontal Disease and Post-menopausal Osteoporosis	https://ClinicalTrials.gov/show/NCT02184962	Completed	Universidad Nacional de Córdoba	2013-09-30
NCT02177591	Observational Study of the Association Between Periodontal Disease and Cardiovascular Disease	https://ClinicalTrials.gov/show/NCT02177591	Completed	Texas Tech University Health Sciences Center	2015-05-31
NCT02127203	Nitro-oxidative Stress in Periodontitis	https://ClinicalTrials.gov/show/NCT02127203	Completed	Damascus University	2015-09-30
NCT04450810	Role of ET-1 in Periodontitis and Diabetes	https://ClinicalTrials.gov/show/NCT04450810	Completed	University of Messina	2019-12-28
NCT01881074	Periodontal Treatment Response in Type II Diabetic Patients	https://ClinicalTrials.gov/show/NCT01881074	Completed	University of Florida	2015-12-31
NCT01785355	The Impact Of Periodontal Disease Treatment On The General Health Status In Chronic Haemodialyzed Patients	https://ClinicalTrials.gov/show/NCT01785355	Recruiting	Anemia Working Group Romania	2021-09-30
NCT01584479	Periodontal Disease Prevention Study	https://ClinicalTrials.gov/show/NCT01584479	Completed	University of Michigan	2012-03-31
NCT01568697	Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)	https://ClinicalTrials.gov/show/NCT01568697	Recruiting	National Institutes of Health Clinical Center (CC)	NA
NCT01489839	Biomarkers of Periodontal Disease Progression	https://ClinicalTrials.gov/show/NCT01489839	Completed	The Forsyth Institute	2016-06-30
NCT01399034	Epigenetics, DNA Methylation Patterns and Periodontal Disease	https://ClinicalTrials.gov/show/NCT01399034	Completed	University of North Carolina, Chapel Hill	2011-02-28
NCT01376791	Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults	https://ClinicalTrials.gov/show/NCT01376791	Completed	San Diego State University	2012-12-31
NCT04417322	Serum A.Actinomycetemcomitans Antibodies and Periodontitis	https://ClinicalTrials.gov/show/NCT04417322	Completed	University of Messina	2020-03-02
NCT04407026	Oral and Systemic Levels of TFF-1 and TTF-3 in Periodontal Diseases	https://ClinicalTrials.gov/show/NCT04407026	Completed	Aydin Adnan Menderes University	2018-03-01
NCT04382105	Serum P.Gingivalis Antibodies and Periodontitis	https://ClinicalTrials.gov/show/NCT04382105	Completed	University of Messina	2020-02-15
NCT04381273	Oral Health and Psychosocial Factors During the Covid-19 Pandemic	https://ClinicalTrials.gov/show/NCT04381273	Recruiting	Heidelberg University	2020-07-31
NCT04380922	Prevalence of Periodontal Diseases in IBD	https://ClinicalTrials.gov/show/NCT04380922	Recruiting	CHU de Reims	2021-07-19
NCT04335344	Role of suPAR in Periodontitis and CVD	https://ClinicalTrials.gov/show/NCT04335344	Completed	University of Messina	2018-09-21
NCT04274855	Effect of Trait Anxiety in Women on Oral Health Status and Oral Health Care-Seeking Behavior	https://ClinicalTrials.gov/show/NCT04274855	Recruiting	Ain Shams University	2020-11-30
NCT04271787	New Periodontal Classification	https://ClinicalTrials.gov/show/NCT04271787	Completed	Beni-Suef University	2019-06-30
NCT04268381	Oral and Systemic aMMP-8 in Periodontal Disease	https://ClinicalTrials.gov/show/NCT04268381	Recruiting	Aydin Adnan Menderes University	2020-03-20
NCT04253613	Laser Biostimulation in Periodontal Treatment	https://ClinicalTrials.gov/show/NCT04253613	Completed	Ondokuz Mayıs University	2014-06-15
NCT04209231	Effect of Vitamin D on Periodontal Disease	https://ClinicalTrials.gov/show/NCT04209231	Completed	Recep Tayyip Erdogan University Training and Research Hospital	2016-04-30
NCT04143568	Circulating Progenitor Cells Levels in Periodontal Disease Patients	https://ClinicalTrials.gov/show/NCT04143568	Completed	University of Messina	2018-10-30
NCT04135222	Evaluation of Periodontal Phenotype Using CBCT, Computed Aided Design (CAD) and Prosthetic-driven Implant Planing (PDIP).	https://ClinicalTrials.gov/show/NCT04135222	Completed	Wroclaw Medical University	2019-05-13
NCT04127487	Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects	https://ClinicalTrials.gov/show/NCT04127487	Recruiting	Meenakshi Ammal Dental College and Hospital	2020-11-01
NCT04127474	Expression of Trefoil Factors and Adrenomedullin in Subjects With Chronic Periodontitis and Coronary Heart Disease	https://ClinicalTrials.gov/show/NCT04127474	Recruiting	Meenakshi Ammal Dental College and Hospital	2019-12-20
NCT04081025	Oral Health and Risk Factors for Oral Disease	https://ClinicalTrials.gov/show/NCT04081025	Active, not recruiting	Dalarna County Council, Sweden	2020-12-30
NCT04045808	Relationship of Oral Status to Coronary Artery Disease	https://ClinicalTrials.gov/show/NCT04045808	Completed	Baskent University	2011-01-01
NCT04024644	Third Molar: Caries, Periodontal Disease and Quality of Life	https://ClinicalTrials.gov/show/NCT04024644	Completed	University of Sao Paulo	2013-10-01
NCT04017078	Assessment of Carotid Artery Calcifications	https://ClinicalTrials.gov/show/NCT04017078	Completed	Baskent University	2018-09-25
NCT04012983	Possible Role of Gingival Crevicular Fluid Levels of Chemerin and Fibroblast Growth Factor 21 as Biomarkers of Periodontal Disease in Diabetic and Non-diabetic Patients	https://ClinicalTrials.gov/show/NCT04012983	Completed	Cairo University	2018-08-01
NCT03934957	Hamburg City Health Study - a German Cohort Study	https://ClinicalTrials.gov/show/NCT03934957	Recruiting	Universitätsklinikum Hamburg-Eppendorf	2022-12-31
NCT03910205	Tumor Necrosis Factor-alpha and Interleukin-18 Levels in Children With Gingivitis and Type 1 Diabetes Mellitus	https://ClinicalTrials.gov/show/NCT03910205	Completed	Aydin Adnan Menderes University	2019-06-30
NCT03809676	Periodontal Status and Dental Behavior of Heart Trasplant Recipients and Healthy Controls	https://ClinicalTrials.gov/show/NCT03809676	Completed	Baskent University	2019-01-10
NCT03775967	Estimation of Sialic Acid and IL10 Levels in Stage 1 and 2 Periodontitis Patients	https://ClinicalTrials.gov/show/NCT03775967	Completed	Ajman University	2019-01-10
NCT03727035	Quantification of CD163 Inflammatory Biomarker in Chronic Periodontitis and Diabetic Subjects	https://ClinicalTrials.gov/show/NCT03727035	Recruiting	Meenakshi Ammal Dental College and Hospital	2019-11-30
NCT03721159	Quantification of Micro-RNA 146-a in Chronic Periodontitis and Coronary Heart Disease Subjects	https://ClinicalTrials.gov/show/NCT03721159	Completed	Meenakshi Ammal Dental College and Hospital	2018-09-01
NCT03703648	Post-radiation Dental Disease Amongst Head and Neck Cancer Patients	https://ClinicalTrials.gov/show/NCT03703648	Recruiting	Belfast Health and Social Care Trust	2023-05-31
NCT03660410	Study of Oral Conditions in Indigenous Populations in the State of Roraima - Brazil	https://ClinicalTrials.gov/show/NCT03660410	Completed	Universidade Metropolitana de Santos	2017-05-02
NCT03649789	Periodontal Outcomes After Sanative Therapy	https://ClinicalTrials.gov/show/NCT03649789	Completed	Brock University	2019-03-30
NCT03648723	The Effect of Periodontal Disease Treatment in Patients With Kidney Disease	https://ClinicalTrials.gov/show/NCT03648723	Completed	TC Erciyes University	2017-01-10
NCT03610841	Evaluation of the Possible Relationship Between Periodontal Disease and Preterm Labor	https://ClinicalTrials.gov/show/NCT03610841	Recruiting	Recep Tayyip Erdogan University Training and Research Hospital	2018-09-17
NCT03594968	Oxidative Stress in Polycystic Ovary Syndrome With Periodontal Disease and Dental Caries Lesions	https://ClinicalTrials.gov/show/NCT03594968	Recruiting	Recep Tayyip Erdogan University Training and Research Hospital	2019-03-30
NCT03558906	TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases	https://ClinicalTrials.gov/show/NCT03558906	Completed	Aydin Adnan Menderes University	2016-03-02
NCT03470987	The Role of Visfatin in Obesity and Periodontal Disease	https://ClinicalTrials.gov/show/NCT03470987	Completed	Gazi University	2014-09-30
NCT03437798	Genomic Determinants and Shared Genetic Pathways of Periodontal Disease	https://ClinicalTrials.gov/show/NCT03437798	Recruiting	Tufts University	2022-05-31
NCT01234948	Oral Malodour and Periodontal Disease-related Parameters	https://ClinicalTrials.gov/show/NCT01234948	Completed	Aristotle University Of Thessaloniki	2009-01-31
NCT01180920	The Importance of Periostin in Periodontal Health and Disease	https://ClinicalTrials.gov/show/NCT01180920	Completed	University of Michigan	2013-02-28
NCT01156155	Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis	https://ClinicalTrials.gov/show/NCT01156155	Completed	University of Nebraska	2012-07-31
NCT01154855	Periodontal Disease and Circulatory Microbial Components	https://ClinicalTrials.gov/show/NCT01154855	Completed	University of Michigan	2015-05-31
NCT01130207	Microbes and Bariatric Surgery	https://ClinicalTrials.gov/show/NCT01130207	Completed	State University of New York - Upstate Medical University	2013-08-31
NCT00855504	Association of Periodontitis and Preeclampsia During Pregnancy	https://ClinicalTrials.gov/show/NCT00855504	Completed	Maulana Azad Medical College	2011-09-30
NCT01693731	Oral Health in Breast Cancer Survivors on Aromatase Inhibitors	https://ClinicalTrials.gov/show/NCT01693731	Completed	University of Michigan	2015-03-31
NCT03603236	Evaluation of the Possible Relationship Between Preeclampsia and Periodontal Disease	https://ClinicalTrials.gov/show/NCT03603236	Recruiting	Recep Tayyip Erdogan University Training and Research Hospital	2018-09-17
NCT03507868	YKL-40 and IL-6 Levels in Periodontal Disease	https://ClinicalTrials.gov/show/NCT03507868	Completed	Aydin Adnan Menderes University	2017-04-30
NCT03132207	The 4th Month Oral Consultation at Pregnant Women	https://ClinicalTrials.gov/show/NCT03132207	Completed	Nantes University Hospital	2018-03-16
NCT02941887	Global Behavior and Periodontal Disease in Down’s Syndrome Patients	https://ClinicalTrials.gov/show/NCT02941887	Completed	University of Sao Paulo	2016-10-31
NCT00569075	Apoptic Biomarkers of Periodontal Disease	https://ClinicalTrials.gov/show/NCT00569075	Completed	University of Michigan	2009-10-31
NCT00490165	Periodontal and Periapical Inflammation and Pregnancy	https://ClinicalTrials.gov/show/NCT00490165	Completed	University of Mississippi Medical Center	2011-12-31
NCT00001726	Study of the Composition of Dental Plaque	https://ClinicalTrials.gov/show/NCT00001726	Completed	National Institutes of Health Clinical Center (CC)	2009-08-03

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03407911	Microbiota Around Periodontal Teeth and Implants Affected by Peri-implant Disease.	https://ClinicalTrials.gov/show/NCT03407911	Completed	Azienda Ospedaliera, Universitaria Policlinico Vittorio Emanuele	2018-04-01
NCT03088228	Maternal Periodontal Status and Cytokines in Preeclampsia	https://ClinicalTrials.gov/show/NCT03088228	Completed	Yuzuncu Yıl University	2016-08-15
NCT01900535	Evaluation and Comparison of the Efficacy of Triphala Mouthwash and 0.2% Chlorhexidine	https://ClinicalTrials.gov/show/NCT01900535	Completed	Tatyasaheb Kore Dental College	2013-02-28
NCT01866761	Relationship Analysis Between Periodontal Disease and Atherosclerosis in Japanese Medical Cooperation Services	https://ClinicalTrials.gov/show/NCT01866761	Completed	Okayama University	2012-01-31
NCT03805724	Entamoeba Gingivalis and Periodontal Disease	https://ClinicalTrials.gov/show/NCT03805724	Completed	Cairo University	2019-01-18
NCT03789565	Hepcidin Levels in Periodontal Health and Disease	https://ClinicalTrials.gov/show/NCT03789565	Completed	Bulent Ecevit University	2018-01-20
NCT03663140	Neurogenic Inflammation in Peri-implant and Periodontal Diseases	https://ClinicalTrials.gov/show/NCT03663140	Completed	Ondokuz Mayıs University	2013-09-15
NCT03549247	Oral Health Related Quality of Life and Periodontal Diseases	https://ClinicalTrials.gov/show/NCT03549247	Completed	Ondokuz Mayıs University	2017-07-30
NCT03527901	Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease	https://ClinicalTrials.gov/show/NCT03527901	Completed	Aydin Adnan Menderes University	2016-03-01
NCT03788473	"Periodontal Disease as a Possible Risk Factor for Complications During Pregnancy and Childbirth	https://ClinicalTrials.gov/show/NCT03788473	Recruiting	Universidad de Granada	2019-07-26